Redirecting an organism’s metabolism towards novel products raises a number of design issues. What is the impact of the new pathway on the cell’s energy and redox metabolism? Can the precursor and coenzyme requirements be satisfied? Should some parts of the metabolic network be blocked off to ensure the most efficient routes to the product are favoured? Answering these questions needs tools that can compute and compare feasible routes through the cell’s metabolic network, as well as methods for defining and representing the metabolic network in a way the tools can use. This is the domain of structural analysis of metabolism, and techniques such as elementary modes analysis and flux balance analysis. This combined theoretical and practical course will explain the theory behind these techniques and give hands-on experience of building metabolic network models and calculating feasible and optimal routes through them. It will be presented by David Fell and his colleagues in the Cell Systems Modelling Group of Oxford Brookes University. It covers the same area as the previous C1net Modelling Workshop 1, but is complementary to Workshop 2 on kinetic models.
Free participation, accommodation (for non-local delegates) and meals for members of C1NET or another NIBB network. Participants are required to bring their own laptop (not netbook or tablet). Software will be provided.
When: Monday 23 January 2017, 13.30 – Friday 27 January 2017 13:30
Where: St James Hotel, 1 Rutland Street, Nottingham, Nottinghamshire, NG1 6FL